Index was outside the bounds of the array. 文章摘要
|本期目录/Table of Contents|

[1]梅嘉伦,张长青,高俊杰.线粒体DNA甲基化在骨骼系统中的作用机制[J].国际骨科学杂志,2024,02:131-135.
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线粒体DNA甲基化在骨骼系统中的作用机制(PDF)

《国际骨科学杂志》[ISSN:1673-7083/CN:31-1952/R]

期数:
2024年02期
页码:
131-135
栏目:
综述
出版日期:
2024-03-25

文章信息/Info

Title:
-
作者:
梅嘉伦张长青高俊杰
200233,? 上海交通大学医学院附属第六人民医院骨科、显微外科研究所
Author(s):
-
关键词:
线粒体基因甲基化骨骼系统线粒体骨发育骨代谢
Keywords:
-
分类号:
-
DOI:
10.3969/j.issn.1673-7083.2024.02.012
文献标识码:
-
摘要:
线粒体作为细胞内最关键的能量代谢细胞器,可在通过氧化磷酸化(OXPHOS)生成三磷酸腺苷(ATP)、调控细胞凋亡和维持钙平衡等方面发挥重要作用,而线粒体DNA(mtDNA)可深度调控线粒体基本功能。mtDNA也可受到精准调控,其甲基化是一种重要的表观遗传机制。近年来越来越多的研究表明,mtDNA的表观遗传学修饰可参与多种骨骼系统疾病的发生与发展。该文将从饮食、代谢、发育衰老等多个维度探讨mtDNA甲基化对骨骼系统的潜在影响,为未来预防和个性化治疗骨骼系统疾病提供新方向。
Abstract:
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备注/Memo

备注/Memo:
通信作者:高俊杰? E-mail: colingjj@163.com
? ? ? ? ? 张长青 ?E-mail: zhangcq@sjtu.edu.cn
更新日期/Last Update: 2024-03-25