索引超出了数组界限。 文章摘要
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[1]殷翰林,邓国英,赵庆华.干细胞移植前处理治疗椎间盘退行性病变研究进展[J].国际骨科学杂志,2017,05:299-302.
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干细胞移植前处理治疗椎间盘退行性病变研究进展(PDF)

《国际骨科学杂志》[ISSN:1673-7083/CN:31-1952/R]

期数:
2017年05期
页码:
299-302
栏目:
综述
出版日期:
2017-09-20

文章信息/Info

Title:
-
作者:
殷翰林; 邓国英; 赵庆华
201620, 上海交通大学附属第一人民医院骨科
Author(s):
-
关键词:
椎间盘退行性病变;  干细胞移植;  前处理
Keywords:
-
分类号:
-
DOI:
10.3969/j.issn.1673-7083.2017.05.006
文献标识码:
A
摘要:
椎间盘退行性病变的治疗方案主要侧重于缓解疼痛症状,但无法阻止退行性病变进程。基于此,干细胞移植治疗成为该领域的研究热点,其中干细胞移植前处理对治疗效果起决定性作用。目前移植前处理方法包括髓核细胞共培养、生长因子处理、低氧处理、转染、组织工程复合体及力学刺激。髓核细胞共培养可促进干细胞向髓核细胞表型分化; 生长因子种类及浓度可调控干细胞的生长、分化; 低氧环境前处理可显著增强干细胞的抗逆境能力; 基因转染可有效调节干细胞分化,并增强其旁分泌能力; 组织工程复合体可改善微环境,从而有利于维持干细胞活性; 力学刺激可正性调控骨髓间充质干细胞的软骨样分化。该文就干细胞移植前处理治疗椎间盘退行性病变研究进展作一综述。
Abstract:
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参考文献/References

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备注/Memo

备注/Memo:
基金项目: 上海市浦江人才计划项目资助基金(16PJD040)、上海交通大学“医工交叉基金”项目(YG2016MS19)
通信作者: 赵庆华 E-mail: sawboneszhao@163.com
更新日期/Last Update: 2017-09-20