索引超出了数组界限。 文章摘要
|本期目录/Table of Contents|

[1]刘斌,鲜艳思,郭保生,等.骨关节炎中滑膜炎症致病因素的研究进展[J].国际骨科学杂志,2023,05:274-278.
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骨关节炎中滑膜炎症致病因素的研究进展(PDF)

《国际骨科学杂志》[ISSN:1673-7083/CN:31-1952/R]

期数:
2023年05期
页码:
274-278
栏目:
综述
出版日期:
2023-09-30

文章信息/Info

Title:
-
作者:
刘斌; 鲜艳思; 郭保生; 蒋青
南京大学医学院附属鼓楼医院骨科、运动医学与成人重建外科、国家骨科与运动康复临床医学研究中心分中心
Author(s):
-
关键词:
骨关节炎; 滑膜; 炎症; 成纤维细胞; 巨噬细胞
Keywords:
-
分类号:
-
DOI:
10.3969/j.issn. 1673-7083.2023.05.002
文献标识码:
-
摘要:
骨关节炎（OA）是以关节疼痛、肿胀、活动障碍为特征的退行性骨科疾病。除软骨磨损外，滑膜炎症在 OA 病理改变中的作用同样值得关注，其与疼痛症状密切相关，并具有判断预后的价值。关节内外多种因素均可导致 滑膜炎症的产生，OA 发生时关节内多种结构炎症因子产生增多，与软骨退变后释放的磨损颗粒、含钙晶体、细胞外 囊泡等共同构成关节腔的炎症微环境，可上调滑膜中成纤维细胞和巨噬细胞的炎症基因表达。此外，滑膜受力异常、 滑膜中衰老细胞增多也可参与滑膜炎症的发生，而肥胖、糖尿病引起的全身代谢紊乱则可通过激活炎症通路、影响 胰岛素敏感性等加剧滑膜炎症。该文就OA 中滑膜炎症致病因素的研究进展进行综述。
Abstract:
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备注/Memo

备注/Memo:
基金项目：国家重点研发计划（2021YFA1201404）、国家自然科学基 金（81991514）、江苏省研究生科研创新计划（KYCX23_0190）
通信作者：蒋青 E-mail: qingj@nju.edu.cn
更新日期/Last Update: 2023-09-30