[1]刘哲,唐千,位晓娟,等.血小板衍生物在骨关节炎治疗中的应用[J].国际骨科学杂志,2022,06:335-338.
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血小板衍生物在骨关节炎治疗中的应用(PDF)
《国际骨科学杂志》[ISSN:1673-7083/CN:31-1952/R]
- 期数:
- 2022年06期
- 页码:
- 335-338
- 栏目:
- 综述
- 出版日期:
- 2022-12-01
文章信息/Info
- Title:
- -
- 文章编号:
- 10.3969/j.issn.1673-7083.2022.06.003
- 作者:
- 刘哲;唐千;位晓娟;张长青;朱振中;
- 200233， 上海交通大学医学院附属第六人民医院骨科
- Author(s):
- -
- Keywords:
- -
- 分类号:
- -
- DOI:
- -
- 文献标识码:
- -
- 摘要:
- 骨关节炎(OA) 是一种进展性的慢性退行性关节疾病，目前临床针对早中期OA 的有效治疗手段仍十分有限。 血小板衍生物是一类来源于血小板的生物制剂，包括富血小板血浆（PRP）、血小板裂解液（PL）及血小板源性外泌 体（PL-exo），因其富含多种生物活性分子而被广泛应用于组织的再生修复。近10 年来，众多研究表明，相较于口服 非甾体类抗炎药或关节腔注射透明质酸钠等传统手段，关节腔注射血小板衍生物能更好地促进OA 关节软骨修复，延 缓疾病进展，并改善其预后。血小板衍生物的潜在分子机制可能与其所富含的生物活性分子对软骨细胞增殖、细胞 外基质代谢及软骨细胞炎症反应等生物学行为的调控相关。该文就血小板衍生物在OA 治疗中的研究进展进行综述。
- Abstract:
- -
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备注/Memo
- 备注/Memo:
-
基金项目：国家自然科学基金（82172400）
通信作者：朱振中 E-mail: zzz1129@qq.com
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