索引超出了数组界限。 文章摘要
|本期目录/Table of Contents|

[1]王鑫,付海亮.外泌体在骨科疾病治疗中的作用[J].国际骨科学杂志,2021,02:102-105.
点击复制

外泌体在骨科疾病治疗中的作用(PDF)

《国际骨科学杂志》[ISSN:1673-7083/CN:31-1952/R]

期数:
2021年02期
页码:
102-105
栏目:
综述
出版日期:
2021-04-20

文章信息/Info

Title:
-
作者:
王鑫付海亮
150001, 哈尔滨医科大学附属第二医院骨外科
Author(s):
-
关键词:
外泌体 骨关节炎 骨质疏松 股骨头坏死 骨折 骨缺损
Keywords:
-
分类号:
-
DOI:
10.3969/j.issn.1673-7083.2021.02.009
文献标识码:
-
摘要:
外泌体是一种由各种类型细胞分泌的囊泡,它经由脂质膜包裹着各种核酸、蛋白质、脂质等生物活性物质。基础研究显示,各种来源的外泌体治疗骨关节炎、骨质疏松、糖皮质激素性股骨头坏死、骨缺损、骨折等骨科疾病取得良好效果。其作用机制涉及各种基因表达调控及各种信号转导通路激活,从而调控软骨细胞、成骨细胞、破骨细胞、血管内皮细胞等生理活动。该文就外泌体在骨科疾病治疗中的作用作一综述。
Abstract:
-

参考文献/References

[1] Burger D, Vinas JL, Akbari S, et al. Human endothelial colony-forming cells protect against acute kidney injury: role of exosomes[J]. Am J Pathol, 2015, 185(8): 2309-2323.
[2] de Jong OG, van Balkom BW, Schiffelers RM, et al. Extracellular vesicles: potential roles in regenerative medicine[J]. Front Immunol, 2014, 5: 608.
[3] Tao SC, Yuan T, Zhang YL, et al. Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model[J]. Theranostics, 2017, 7(1): 180-195.
[4] Ge X, Shi R, Ma X. The secreted protein WNT5A regulates condylar chondrocyte proliferation, hypertrophy and migration[J]. Arch Oral Biol, 2017, 82: 171-179.
[5] Mao G, Zhang Z, Hu S, et al. Exosomes derived from miR-92a-3p-overexpressing human mesenchymal stem cells enhance chondrogenesis and suppress cartilage degradation via targeting WNT5A[J]. Stem Cell Res Ther, 2018, 9(1): 247.
[6] Liu Y, Lin L, Zou R, et al. MSC-derived exosomes promote proliferation and inhibit apoptosis of chondrocytes via lncRNA-KLF3-AS1/miR-206/GIT1 axis in osteoarthritis[J]. Cell Cycle, 2018, 17(21-22): 2411-2422.
[7] Zhang LQ, Zhao GZ, Xu XY, et al. Integrin-beta1 regulates chondrocyte proliferation and apoptosis through the upregulation of GIT1 expression[J]. Int J Mol Med, 2015, 35(4): 1074-1080.
[8] Zhao GZ, Zhang LQ, Liu Y, et al. Effects of platelet-derived growth factor on chondrocyte proliferation, migration and apoptosis via regulation of GIT1 expression[J]. Mol Med Rep, 2016, 14(1): 897-903.
[9] Liu Y, Zou R, Wang Z, et al. Exosomal KLF3-AS1 from hMSCs promoted cartilage repair and chondrocyte proliferation in osteoarthritis[J]. Biochem J, 2018, 475(22): 3629-3638.
[10] Cosenza S, Ruiz M, Toupet K, et al. Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis[J]. Sci Rep, 2017, 7(1): 16214.
[11] Zhu Y, Wang Y, Zhao B, et al. Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis[J]. Stem Cell Res Ther, 2017, 8(1): 64.
[12] Wang Y, Yu D, Liu Z, et al. Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix[J]. Stem Cell Res Ther, 2017, 8: 189.
[13] Guo SC, Tao SC, Yin WJ, et al. Exosomes from human synovial-derived mesenchymal stem cells prevent glucocorticoid-induced osteonecrosis of the femoral head in the rat[J]. Int J Biol Sci, 2016, 12(10): 1262-1272.
[14] Li H, Liu D, Li C, et al. Exosomes secreted from mutant-HIF-1alpha-modified bone-marrow-derived mesenchymal stem cells attenuate early steroid-induced avascular necrosis of femoral head in rabbit[J]. Cell Biol Int, 2017, 41(12): 1379-1390.
[15] Liu X, Li Q, Niu X, et al. Exosomes secreted from human-induced pluripotent stem cell-derived mesenchymal stem cells prevent osteonecrosis of the femoral head by promoting angiogenesis[J]. Int J Biol Sci, 2017, 13(2): 232-244.
[16] Tao SC, Yuan T, Rui BY, et al. Exosomes derived from human platelet-rich plasma prevent apoptosis induced by glucocorticoid-associated endoplasmic reticulum stress in rat osteonecrosis of the femoral head via the Akt/Bad/Bcl-2 signal pathway[J]. Theranostics, 2017, 7(3): 733-750.
[17] Fang S, Li Y, Chen P. Osteogenic effect of bone marrow mesenchymal stem cell-derived exosomes on steroid-induced osteonecrosis of the femoral head[J]. Drug Des Devel Ther, 2018, 13: 45-55.
[18] Qi X, Zhang J, Yuan H, et al. Exosomes secreted by human-induced pluripotent stem cell-derived mesenchymal stem cells repair critical-sized bone defects through enhanced angiogenesis and osteogenesis in osteoporotic rats[J]. Int J Biol Sci, 2016, 12(7): 836-849.
[19] Chen S, Tang Y, Liu Y, et al. Exosomes derived from miR-375-overexpressing human adipose mesenchymal stem cells promote bone regeneration[J]. Cell Prolif, 2019, 52(5): e12669.
[20] Zhang Y, Hao Z, Wang P, et al. Exosomes from human umbilical cord mesenchymal stem cells enhance fracture healing through HIF-1alpha-mediated promotion of angiogenesis in a rat model of stabilized fracture[J]. Cell Prolif, 2019, 52(2): e12570.
[21] Zhao P, Xiao L, Peng J, et al. Exosomes derived from bone marrow mesenchymal stem cells improve osteoporosis through promoting osteoblast proliferation via MAPK pathway[J]. Eur Rev Med Pharmacol Sci, 2018, 22(12): 3962-3970.
[22] Chen C, Akiyama K, Wang D, et al. mTOR inhibition rescues osteopenia in mice with systemic sclerosis[J]. J Exp Med, 2015, 212(1): 73-91.
[23] Chen C, Wang D, Moshaverinia A, et al. Mesenchymal stem cell transplantation in tight-skin mice identifies miR-151-5p as a therapeutic target for systemic sclerosis[J]. Cell Res, 2017, 27(4): 559-577.
[24] Song H, Li X, Zhao Z, et al. Reversal of osteoporotic activity by endothelial cell-secreted bone targeting and biocompatible exosomes[J]. Nano Lett, 2019, 19(5): 3040-3048.

备注/Memo

备注/Memo:
通信作者: 付海亮 E-mail: 106860696@qq.com
更新日期/Last Update: 2021-04-20