索引超出了数组界限。 文章摘要
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[1]钟京谕 姚伟武.骨关节炎中软骨及软骨下骨间信号交流[J].国际骨科学杂志,2019,04:207-210214.
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骨关节炎中软骨及软骨下骨间信号交流(PDF)

《国际骨科学杂志》[ISSN:1673-7083/CN:31-1952/R]

期数:
2019年04期
页码:
207-210214
栏目:
综述
出版日期:
2019-08-09

文章信息/Info

Title:
-
作者:
钟京谕 姚伟武
200050, 上海交通大学医学院附属同仁医院影像科
Author(s):
-
关键词:
骨关节炎;  骨软骨单元;  信号通路;  软骨;  软骨下骨
Keywords:
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分类号:
-
DOI:
10.3969/j.issn.1673-7083.2019.04.004
文献标识码:
-
摘要:
软骨及软骨下骨间信号交流在骨关节炎(OA)中有重要作用。转化生长因子(TGF)-β/骨形态发生蛋白(BMP)、Wnt、丝裂原活化蛋白激酶(MAPK)信号通路可维持软骨及软骨下骨正常形态与功能。OA中信号通路改变使软骨及软骨下骨稳态失衡,出现软骨基质破坏、骨囊肿和骨赘、骨小梁微骨折等病变,软骨与软骨下骨间的信号交流是OA进展的关键。该文总结了OA中TGF-β/BMP、Wnt、MAPK信号通路在软骨及软骨下骨间交流的机制和作用,以期为OA及其他骨关节疾病研究和治疗带来新的方向。
Abstract:
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参考文献/References

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备注/Memo

备注/Memo:
基金项目: 国家自然科学基金面上项目(81771790)
通信作者: 姚伟武 E-mail: yaoweiwuhuan@163.com
更新日期/Last Update: 2019-08-09