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《国际骨科学杂志》[ISSN:1673-7083/CN:31-1952/R]

期数:

2018年01期

页码:

59-62

栏目:

临床研究

出版日期:

2018-01-30

文章信息/Info

Title:

Efficacy of tranexamic acid in the reduction of perioperative blood loss during primary total hip arthroplasty

作者:

施耀华; 张曦; 伏治国

213003, 江苏省常州市中医医院骨科

Author(s):

SHI Yaohua;  ZHANG Xi;  FU Zhiguo.

Department of Orthopaedics, Changzhou Traditional Chinese Medicine Hospital, Changzhou 213003, China

关键词:

氨甲环酸;  全髋关节置换;  出血量;  输血率

Keywords:

Tranexamic acid;  Total hip arthroplasty;  Blood loss;  Blood transfusion rate

分类号:

-

DOI:

10.3969/j.issn.1673-7083.2018.01.014

文献标识码:

A

摘要:

目的 探讨氨甲环酸(TXA)在初次全髋关节置换术中的应用剂量、效果及并发症发生情况。方法 将常州市中医院2016年2月至2017年1月需行单侧初次全髋关节置换术的65例患者随机分为对照组(20例)、单次组(23例)、重复组(22例)。单次组于术前15 min静脉滴注TXA 15 mg/kg,重复组除在术前15 min静脉滴注TXA 15 mg/kg外,术后3 h静脉滴注TXA 10 mg/kg。比较3组出血量、引流量、输血率、血栓相关事件发生情况。结果 对照组、单次组和重复组术中出血量分别为(485.0±96.1)mL、(354.4±45.0)mL、(320.0±78.7)mL,对照组出血量大于单次组和重复组(P值均<0.001)。对照组、单次组和重复组术后引流量分别为(331.5±70.1)mL、(269.1±61.1)mL、(200.7±43.9)mL,对照组术后引流量大于单次组和重复组(分别为P=0.003和P<0.001),且单次组术后引流量多于重复组(P=0.001)。对照组、单次组和重复组分别有13例(65.0%)、8例(34.8%)、2例(9.1%)输血,对照组输血率高于单次组和重复组(分别为P=0.048和P<0.001),单次组输血率高于重复组(P=0.003 8)。3组血栓相关事件发生率无统计学差异(P>0.05)。结论 静脉滴注TXA可有效减少初次全髋关节置换术中出血量和输血率,其中术后重复使用较术前单次使用效果更佳,且不增加血栓发生率。

Abstract:

Objective To investigate the dose, clinical outcomes and complications of tranexamic acid(TXA)in primary total hip arthroplasty.Methods From February 2016 to January 2017, a total of 65 patients who had to undergo unilateral primary total hip arthroplasty

参考文献/References

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更新日期/Last Update: 2018-01-30