索引超出了数组界限。 文章摘要
|本期目录/Table of Contents|

[1]卢敏强,钟庆,贾兆锋,等.雌激素与骨关节炎[J].国际骨科学杂志,2018,01:41-44.
点击复制

雌激素与骨关节炎(PDF)

《国际骨科学杂志》[ISSN:1673-7083/CN:31-1952/R]

期数:
2018年01期
页码:
41-44
栏目:
综述
出版日期:
2018-01-30

文章信息/Info

Title:
-
作者:
卢敏强; 钟庆; 贾兆锋; 徐晓; 段莉; 王大平
515063, 汕头大学医学院(卢敏强); 421001 衡阳,南华大学(钟庆); 510182, 广州医科大学(贾兆锋、徐晓); 518035, 深圳市第二人民医院组织工程重点实验室(段莉、王大平)
Author(s):
-
关键词:
骨关节炎;  雌激素;  雌激素受体;  微小RNA
Keywords:
-
分类号:
-
DOI:
10.3969/j.issn.1673-7083.2018.01.011
文献标识码:
A
摘要:
骨关节炎(OA)是一种严重损害中老年人健康的骨关节疾病。绝经后女性OA患病率远高于同龄男性及绝经前女性,表明雌激素是参与OA发生和发展的重要调节因子。雌激素需与雌激素受体(ER)结合后起作用,ER包括雌激素核受体(nER)和雌激素膜受体(mER),通过不同作用机制以实现雌激素对关节软骨的保护作用。近期研究发现,OA患者与正常人相比有多种miRNA存在差异性表达,表明miRNA有望成为早期诊治OA的新靶点。本文就雌激素、ER及雌激素和miRNA与OA的研究进展作一综述。
Abstract:
-

参考文献/References

[1] Prieto-Alhambra D, Judge A, Javaid MK, et al. Incidence and risk factors for clinically diagnosed knee, hip and hand osteoarthritis: influences of age, gender and osteoarthritis affecting other joints[J]. Ann Rheum Dis, 2014, 73(9): 1659-1664.
[2] Yu D, Peat G, Bedson J, et al. Annual consultation incidence of osteoarthritis estimated from population-based health care data in England[J]. Rheumatology(Oxford), 2015, 54(11): 2051-2060.
[3] Plotnikoff R, Karunamuni N, Lytvyak E, et al. Osteoarthritis prevalence and modifiable factors: a population study[J]. BMC Public Health, 2015, 15: 1195-1205.
[4] Roos EM, Arden NK. Strategies for the prevention of knee osteoarthritis[J]. Nat Rev Rheumatol, 2016, 12(2): 92-101.
[5] Ushiyama T, Ueyama H, Inoue K, et al. Expression of genes for estrogen receptors alpha and beta in human articular chondrocytes[J]. Osteoarthritis Cartilage, 1999, 7(6): 560-566.
[6] Caiazza F, Ryan EJ, Doherty G, et al. Estrogen receptors and their implications in colorectal carcinogenesis[J]. Front Oncol, 2015, 5: 19-28.
[7] Wen Y, Li J, Wang L, et al. UDP-glucose dehydrogenase modulates proteoglycan synthesis in articular chondrocytes: its possible involvement and regulation in osteoarthritis[J]. Arthritis Res Ther, 2014, 16(6): 484-495.
[8] Rasheed Z, Rasheed N, Al-Shobaili HA. Epigallocatechin-3-O-gallate up-regulates microRNA-199a-3p expression by down-regulating the expression of cyclooxygenase-2 in stimulated human osteoarthritis chondrocytes[J]. J Cell Mol Med, 2016, 20(12): 2241-2248.
[9] Frederick ED, Hausburg MA, Thomas GW, et al. The low molecular weight fraction of human serum albumin upregulates COX2, prostaglandin E2, and prostaglandin D2 under inflammatory conditions in osteoarthritic knee synovial fibroblasts[J]. Biochem Biophys Rep, 2016, 8: 68-74.
[10] Oestergaard S, Sondergaard BC, Hoegh-Andersen P, et al. Effects of ovariectomy and estrogen therapy on type Ⅱ collagen degradation and structural integrity of articular cartilage in rats: implications of the time of initiation[J]. Arthritis Rheum, 2006, 54(8): 2441-2451.
[11] Maneix L, Servent A, Porée B, et al. Up-regulation of type Ⅱ collagen gene by 17β-estradiol in articular chondrocytes involves Sp1/3, Sox-9, and estrogen receptor α[J]. J Mol Med(Berl), 2014, 92(11): 1179-1200.
[12] Mcdaniel JS, Akula Suresh Babu R, Navarro MM, et al. Transcriptional regulation of proteoglycan 4 by 17β-estradiol in immortalized baboon temporomandibular joint disc cells[J]. Eur J Oral Sci, 2014, 122(2): 100-108.
[13] Polur I, Kamiya Y, Xu M, et al. Oestrogen receptor beta mediates decreased occlusal loading induced inhibition of chondrocyte maturation in female mice[J]. Arch Oral Biol, 2015, 60(6): 818-824.
[14] Shi S, Zheng S, Li XF, et al. The effect of estradiol on the growth plate chondrocytes of limb and spine from postnatal mice in vitro: the role of estrogen-receptor and estradiol concentration[J]. Int J Biol Sci, 2017, 13(1): 100-109.
[15] Lampropoulou-Adamidou K, Lelovas P, Karadimas EV, et al. Useful animal models for the research of osteoarthritis[J]. Eur J Orthop Surg Traumatol, 2014, 24(3): 263-271.
[16] Ham KD, Loeser RF, Lindgren BR, et al. Effects of long-term estrogen replacement therapy on osteoarthritis severity in cynomolgus monkeys[J]. Arthritis Rheum, 2002, 46(7): 1956-1964.
[17] Ma HL, Blanchet TJ, Peluso D, et al. Osteoarthritis severity is sex dependent in a surgical mouse model[J]. Osteoarthritis Cartilage, 2007, 15(6): 695-700.
[18] Yan JY, Tian FM, Wang WY, et al. Age dependent changes in cartilage matrix, subchondral bone mass, and estradiol levels in blood serum, in naturally occurring osteoarthritis in Guinea pigs[J]. Int J Mol Sci, 2014, 15(8): 13578-13595.
[19] Casta?eda S, Largo R, Calvo E, et al. Effects of estrogen deficiency and low bone mineral density on healthy knee cartilage in rabbits[J]. J Orthop Res, 2010, 28(6): 812-818.
[20] Xiao YP, Tian FM, Dai MW, et al. Are estrogen-related drugs new alternatives for the management of osteoarthritis?[J]. Arthritis Res Ther, 2016, 18: 151.
[21] Richette P, Dumontier MF, Fransois M, et al. Dual effects of 17beta-oestradiol on interleukin 1beta-induced proteoglycan degradation in chondrocytes[J]. Ann Rheum Dis, 2004, 63(2): 191-199.
[22] Sharma D, Liu Y, Uht RM. Estradiol(E2)- and tamoxifen(Tmx)-bound ER-alpha(ERα)interact differentially with histone deacetylases 1 and 3(HDACs 1 and 3)[J]. J Steroid Biochem Mol Biol, 2017, 174: 128-132.
[23] Zeng K, Zhang HQ, Chen Y, et al. Estradiol via estrogen receptor beta inhibits chondrogenesis of mouse vertebral growth plate in vitro[J]. Childs Nerv Syst, 2016, 32(3): 461-465.
[24] Kim KH, Young BD, Bender JR. Endothelial estrogen receptor isoforms and cardiovascular disease[J]. Mol Cell Endocrinol, 2014, 389(1/2): 65-70.
[25] Wu Q, Chambliss K, Umetani M, et al. Non-nuclear estrogen receptor signaling in the endothelium[J]. J Biol Chem, 2011, 286(17): 14737-14743.
[26] 闫懿, 敖锋, 宋健. 雌激素及雌激素受体信号转导途径的研究进展[J]. 山西医药杂志, 2016, 45(9): 1032-1034.
[27] Oshima Y, Matsuda K, Yoshida A, et al. Localization of estrogen receptors alpha and beta in the articular surface of the rat femur[J]. Acta Histochem Cytochem, 2007, 40(1): 27-34.
[28] Cheung E, Schwabish MA, Kraus WL. Chromatin exposes intrinsic differences in the transcriptional activities of estrogen receptors alpha and beta[J]. EMBO J, 2003, 22(3): 600-611.
[29] Zhang E, Zhang H, Liu F, et al. Estrogen exerts anti-inflammatory effects by inhibiting NF-κB pathway through binding with estrogen receptor β on synovicytes of osteoarthritis[J]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2016, 32(12): 1605-1609.
[30] Iliopoulos D, Malizos KN, Oikonomou P, et al. Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks[J]. PLoS One, 2008, 3(11): e3740.
[31] Li HR, Cui Q, Dong ZY, et al. Downregulation of miR-27b is Involved in Loss of Type Ⅱ Collagen by Directly Targeting Matrix Metalloproteinase 13(MMP13)in Human Intervertebral Disc Degeneration[J]. Spine(Phila Pa 1976), 2016, 41(3): E116-E123.
[32] Dudek KA, Lafont JE, Martinez-Sanchez A, et al. Type Ⅱ collagen expression is regulated by tissue-specific miR-675 in human articular chondrocytes[J]. J Biol Chem, 2010, 285(32): 24381-24387.
[33] Liang Y, Duan L, Xiong J, et al. E2 regulates MMP-13 via targeting miR-140 in IL-1β-induced extracellular matrix degradation in human chondrocytes[J]. Arthritis Res Ther, 2016, 18(1): 105-114.
[34] Nonaka R, Miyake Y, Hata T, et al. Circulating miR-103 and miR-720 as novel serum biomarkers for patients with colorectal cancer[J]. Int J Oncol, 2015, 47(3): 1097-1102.
[35] Toiyama Y, Okugawa Y, Tanaka K, et al. A panel of methylated microRNA biomarkers for identifying high-risk patients with ulcerative colitis-associated colorectal cancer[J]. Gastroenterology, 2017, 153(6): 1634-1646.e8.

备注/Memo

备注/Memo:
通信作者: 王大平 E-mail: dapingwang1963@qq.com
更新日期/Last Update: 2018-01-30