索引超出了数组界限。 文章摘要
|本期目录/Table of Contents|

[1]许克寒,肖建如.骨微环境在骨转移瘤形成早期的作用[J].国际骨科学杂志,2018,01:37-40.
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骨微环境在骨转移瘤形成早期的作用(PDF)

《国际骨科学杂志》[ISSN:1673-7083/CN:31-1952/R]

期数:
2018年01期
页码:
37-40
栏目:
综述
出版日期:
2018-01-30

文章信息/Info

Title:
-
作者:
许克寒; 肖建如
200003, 上海长征医院骨肿瘤科
Author(s):
-
关键词:
骨微环境;  转移瘤细胞;  休眠;  成骨细胞;  破骨细胞
Keywords:
-
分类号:
-
DOI:
10.3969/j.issn.1673-7083.2018.01.010
文献标识码:
A
摘要:
骨是多种实体肿瘤的常见转移部位之一,肿瘤细胞与骨细胞之间关系密切且相互作用复杂。近期研究发现肿瘤细胞在肿瘤形成早期即可到达骨组织并定植,经长期休眠后少数肿瘤细胞会发展成为骨转移瘤。因此,可将骨转移瘤的形成分为定植、休眠、再活化和增殖4个阶段,但目前对骨转移瘤形成早期的定植、休眠和再活化阶段知之甚少。该文就骨细胞在骨转移瘤形成早期的作用和分子机制作一综述。
Abstract:
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参考文献/References

[1] Bonetto R, Tallet A, Melot A, et al. The management of bone metastasis[J]. Bull Cancer, 2017, 104(6): 585-592.
[2] Coleman RE. Metastatic bone disease: clinical features, pathophysiology and treatment strategies[J]. Cancer Treat Rev, 2001, 27(3): 165-176.
[3] Croucher PI, McDonald MM, Martin TJ. Bone metastasis: the importance of the neighbourhood[J]. Nat Rev Cancer, 2016, 16(6): 373-386.
[4] Futakuchi M, Fukamachi K, Suzui M.Heterogeneity of tumor cells in the bone microenvironment: mechanisms and therapeutic targets for bone metastasis of prostate or breast cancer[J]. Adv Drug Deliv Rev, 2016, 99(Pt B): 206-211.
[5] Boyle WJ, Simonet WS, Lacey DL. Osteoclast differentiation and activation[J]. Nature, 2003, 423(6937): 337-342.
[6] Ottewell PD, Wang N, Brown HK, et al. Zoledronic acid has differential antitumor activity in the pre- and postmenopausal bone microenvironment in vivo[J]. Clin Cancer Res, 2014, 20(11): 2922-2932.
[7] Buenrostro D, Mulcrone PL, Owens P. The bone microenvironment: a fertile soil for tumor growth[J]. Curr Osteoporos Rep, 2016, 14(4): 151-158.
[8] Andersen TL, Sondergaard TE, Skorzynska KE, et al. A physical mechanism for coupling bone resorption and formation in adult human bone[J]. Am J Pathol, 2009, 174(1): 239-247.
[9] Kusumbe AP. Vascular niches for disseminated tumour cells in bone[J]. J Bone Oncol, 2016, 5(3): 112-116.
[10] Jeong HM, Cho SW, Park SI. Osteoblasts are the centerpiece of the metastatic bone microenvironment[J]. Endocrinol Metab(Seoul), 2016, 31(4): 485-492.
[11] Greenbaum A, Hsu YM, Day RB, et al. CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance[J]. Nature, 2013, 495(7440): 227-230.
[12] Croset M, Goehrig D, Frackowiak A, et al. TWIST1 expression in breast cancer cells facilitates bone metastasis formation[J]. J Bone Miner Res, 2014, 29(8): 1886-1899.
[13] Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial-mesenchymal transition[J]. Nat Rev Mol Cell Biol, 2014, 15(3): 178-196.
[14] Mu LL, Ke F, Guo XL, et al. Neoplasms in the bone marrow niches: disturbance of the microecosystem[J]. Int J Hematol, 2017, 105(5): 558-565.
[15] Scala S. Molecular pathways: targeting the CXCR4-CXCL12 axis: untapped potential in the tumor microenvironment[J]. Clin Cancer Res, 2015, 21(19): 4278-4285.
[16] Bouleftour W, Juignet L, Bouet G, et al. The role of the SIBLING, bone sialoprotein in skeletal biology: contribution of mouse experimental genetics[J]. Matrix Biol, 2016, 52-54: 60-77.
[17] Lamour V, Nokin MJ, Henry A, et al. SIBLING proteins: molecular tools for tumor progression and angiogenesis[J]. Med Sci(Paris), 2013, 29(11): 1018-1025.
[18] Lawson MA, McDonald MM, Kovacic N, et al. Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche[J].Nat Commun, 2015,6: 8983.
[19] Vanderkerken K, De Greef C, Asosingh K, et al. Selective initial in vivo homing pattern of 5T2 multiple myeloma cells in the C57BL/KalwRij mouse[J]. Br J Cancer, 2000, 82(4): 953-959.
[20] Shiozawa Y, Pedersen EA, Havens AM, et al. Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow[J]. J Clin Invest, 2011, 121(4): 1298-1312.
[21] Yumoto K, Eber MR, Wang J, et al. Axl is required for TGF-β2-induced dormancy of prostate cancer cells in the bone marrow[J]. Sci Rep, 2016, 6: 36520.
[22] Wang H, Yu C, Gao X, et al. The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells[J]. Cancer Cell, 2015, 27(2): 193-210.
[23] Ghajar CM. Metastasis prevention by targeting the dormant niche[J]. Nat Rev Cancer, 2015, 15(4): 238-247.
[24] Shiozawa Y, Eber MR, Berry JE, et al. Bone marrow as a metastatic niche for disseminated tumor cells from solid tumors[J]. Bonekey Rep, 2015, 4: 689.
[25] Ghajar CM, Peinado H, Mori H, et al. The perivascular niche regulates breast tumour dormancy[J]. Nat Cell Biol, 2013, 15(7): 807-817.
[26] Casimiro S, Ferreira AR, Mansinho A, et al. Molecular mechanisms of bone metastasis: which targets came from the bench to the bedside?[J]. Int J Mol Sci, 2016, 17(9): 1411-1418.
[27] Yu Z, Hong Z, Fong-Yee C, et al. Bone resorption increases tumour growth in a mouse model of osteosclerotic breast cancer metastasis[J]. Clin Exp Metastasis, 2008, 25(5): 559-567.
[28] Kavitha CV, Deep G, Gangar SC, et al. Silibinin inhibits prostate cancer cells- and RANKL-induced osteoclastogenesis by targeting NFATc1, NF-κB, and AP-1 activation in RAW264.7 cells[J]. Mol Carcinog, 2014, 53(3): 169-180.

备注/Memo

备注/Memo:
基金项目: 国家重点基础研究发展计划(Grant2016YFC0902100)
通信作者: 肖建如 E-mail: jianruxiao83@smmu.edu.cn
更新日期/Last Update: 2018-01-30